Having been a Firefox user for a long time I only relatively recently discovered that tabs can be closed with a middle button click. Because of the tab bigger area it's much faster to close it this way than targeting that tiny close button (see Fitts's Law). One especially appreciates this feature when closing multiple tabs. Because the remaining tabs resize after a tab is closed, the close buttons jump over the place. It's pity such neat tricks are not easier discoverable.
I got hooked up on middle-click right away. At some point I found myself repeatedly middle-clicking on tabs in Eclipse to close them. Nothing was happening. I quickly became annoyed and wrote a little Eclipse plugin implementing this functionality.
It turns out there is an Eclipse bug report for this feature. After a short discussion Eclipse developer Boris Bokowski created a patch implementing this feature. Future versions of Eclipse will have this functionality out of the box. Meanwhile you can use the plugin.